Cooney D O, Daly J S
Artif Organs. 1979 Aug;3(3):253-7. doi: 10.1111/j.1525-1594.1979.tb01059.x.
Clearance versus time tests were carried out on three charcoal-based hemoperfusion devices (Sandev, Becton-Dickinson and Gambro) using solutions of 1 gm/L sodium salicylate in a pH 7.4 buffer and in bovine blood at flow rates of 200 ml/min. Similar tests were performed on a Cordis Dow 2.5 m2 hollow-fiber dialyzer at a tube side flow rate (QB) of 200 ml/min. Buffer was pumped through the dialysate side at a flow rate (QD) of 400 ml/min. Two dialyzers were run in series at QB = 200 ml/min and QD = 500 or 1000 ml/min. Mass transfer resistances were computed from the test results. These values are useful in that they constitute an index of the intrinsic initial kinetics of solute transfer in each device. However, the clearance versus time curves indicate that these initial kinetics decrease at different rates for each hemoperfusion unit as sorption capacity begins to be depleted. In contrast, the initial clearances for the dialyzers remain at their initial values. These data reveal much about the relative mass transfer characteristics of these devices.
使用1克/升水杨酸钠在pH 7.4缓冲液和牛血中的溶液，以200毫升/分钟的流速，对三种基于活性炭的血液灌流装置（Sandev、Becton-Dickinson和Gambro）进行了清除率与时间的测试。在管侧流速（QB）为200毫升/分钟的情况下，对Cordis Dow 2.5平方米中空纤维透析器进行了类似测试。缓冲液以400毫升/分钟的流速（QD）泵入透析液侧。两台透析器以QB = 200毫升/分钟和QD = 500或1000毫升/分钟的流速串联运行。根据测试结果计算传质阻力。这些值很有用，因为它们构成了每个装置中溶质转移内在初始动力学的指标。然而，清除率与时间曲线表明，随着吸附容量开始耗尽，每个血液灌流单元的这些初始动力学以不同速率下降。相比之下，透析器的初始清除率保持在其初始值。这些数据揭示了这些装置相对传质特性的许多信息。
