Cooney D O, Infantolino W, Kane R
Biomater Med Devices Artif Organs. 1978;6(3):199-213. doi: 10.3109/10731197809118701.
Drug adsorption studies were carried out using three charcoal-based and one resin-based hemoperfusion devices. They were the Sandev Hemocol unit, the Gambro Adsorba 300C unit unit, the Becton-Dickinson Hemodetoxifier, and the Extracorporeal Medical Specialties XR-010 Hemoperfusion column, respectively. Clearance versus time tests of up to six hours duration were performed using solutions of sodium salicylate, sodium barbital, and creatinine in a pH 7.4 buffer which were pumped through the columns at flow rates of either 100 or 200 ml/minute. Short term clearance tests were performed at various other flow rates to determine overall mass transfer resistances for the devices. Further analysis yielded values for the individual fluid-phase and solid-phase resistances. Studies were also done using sodium salicylate in bovine blood. The results provide information on typical adsorption capacities and drug removal rates for the four devices, and indicate the relative extents to which the solid and fluid phases control the drug uptake rates.
使用三种基于活性炭的血液灌流装置和一种基于树脂的血液灌流装置进行了药物吸附研究。它们分别是Sandev Hemocol装置、Gambro Adsorba 300C装置、Becton-Dickinson血液解毒器和体外医疗专业公司的XR-010血液灌流柱。使用水杨酸钠、巴比妥钠和肌酐在pH 7.4缓冲液中的溶液进行了长达6小时的清除率与时间测试，这些溶液以100或200毫升/分钟的流速泵入柱中。在各种其他流速下进行了短期清除率测试，以确定这些装置的整体传质阻力。进一步分析得出了各个液相传质阻力和固相传质阻力的值。还使用牛血中的水杨酸钠进行了研究。结果提供了这四种装置的典型吸附容量和药物清除率的信息，并表明了固相和液相控制药物摄取率的相对程度。
