• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

石棉小体的蛋白质包被。

The protein coating of asbestos bodies.

作者信息

Blount M, Holt P F, Leach A A

出版信息

Biochem J. 1966 Oct;101(1):204-7. doi: 10.1042/bj1010204.

DOI:10.1042/bj1010204
PMID:5339545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1270084/
Abstract
  1. Asbestos bodies were isolated from human lungs and the amino acid composition of the protein content was determined. 2. The hydroxyproline, glycine, leucine and phenylalanine values indicate that the protein in the coating cannot be principally collagen. 3. Albumin can be adsorbed on chrysotile asbestos as a monolayer but more than a monolayer is adsorbed if iron is also adsorbed. 4. Ferritin is adsorbed on chrysotile to give a thick layer. 5. The amino acid composition and adsorption studies are discussed in the light of the suggestions that the protein coating of asbestos is collagen (Beattie, 1961) or ferritin (Davis, 1964).
摘要
  1. 从人肺中分离出石棉小体,并测定了其蛋白质含量的氨基酸组成。2. 羟脯氨酸、甘氨酸、亮氨酸和苯丙氨酸的值表明,包被中的蛋白质主要不是胶原蛋白。3. 白蛋白可以单层形式吸附在温石棉上,但如果铁也被吸附,则会吸附超过单层的量。4. 铁蛋白吸附在温石棉上形成厚层。5. 根据石棉的蛋白质包被是胶原蛋白(比蒂,1961年)或铁蛋白(戴维斯,1964年)的观点,对氨基酸组成和吸附研究进行了讨论。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b05d/1270084/106bd80d5027/biochemj00750-0214-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b05d/1270084/106bd80d5027/biochemj00750-0214-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b05d/1270084/106bd80d5027/biochemj00750-0214-a.jpg

相似文献

1
The protein coating of asbestos bodies.石棉小体的蛋白质包被。
Biochem J. 1966 Oct;101(1):204-7. doi: 10.1042/bj1010204.
2
Asbestos bodies in rat lung following intratracheal instillation of chrysotile.气管内注入温石棉后大鼠肺中的石棉小体
Lab Anim. 1986 Apr;20(2):132-7. doi: 10.1258/002367786780865223.
3
The mechanism of formation of asbestos bodies.
J Pathol Bacteriol. 1968 Oct;96(2):443-53. doi: 10.1002/path.1700960223.
4
Correlation of asbestos bodies and fibers in lungs of subjects with and without asbestosis.有石棉沉着病和无石棉沉着病受试者肺部石棉小体与纤维的相关性。
Scan Electron Microsc. 1982(Pt 2):845-57.
5
Characterization of asbestos bodies and uncoated fibers in lungs of hamsters.
J Electron Microsc (Tokyo). 1993 Feb;42(1):41-7.
6
Pulmonary fibrogenic response of guinea pigs to amosite dust.
Int Arch Arbeitsmed. 1973;31(1):51-9. doi: 10.1007/BF00538973.
7
Formation of asbestos bodies under the influence of parenteral iron overload.胃肠外铁过载影响下石棉小体的形成
Acta Pharmacol Toxicol (Copenh). 1978 May;42(5):337-42. doi: 10.1111/j.1600-0773.1978.tb02213.x.
8
Physical and microchemical alterations of chrysotile and amosite asbestos in the hamster lung.仓鼠肺中温石棉和铁石棉的物理及微化学变化
J Toxicol Environ Health. 1987;21(3):251-64. doi: 10.1080/15287398709531017.
9
The effects of inhaled crocidolites from Transvaal and North-west Cape mines on the lungs of rats and guinea-pigs.来自德兰士瓦省和开普省西北部矿场的吸入性青石棉对大鼠和豚鼠肺部的影响。
Br J Exp Pathol. 1972 Dec;53(6):612-20.
10
Development of asbestos bodies on amosite, chrysotile and crocidolite fibres in guinea-pig lungs.豚鼠肺中直闪石、温石棉和青石棉纤维上石棉小体的形成。
J Pathol. 1971 Nov;105(3):159-67. doi: 10.1002/path.1711050303.

引用本文的文献

1
An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma.研究铁石棉体内形态:探究其在恶性间皮瘤发病中的作用。
Part Fibre Toxicol. 2023 May 8;20(1):19. doi: 10.1186/s12989-023-00522-0.
2
Asbestos surface provides a niche for oxidative modification.石棉表面为氧化修饰提供了小生境。
Cancer Sci. 2011 Dec;102(12):2118-25. doi: 10.1111/j.1349-7006.2011.02087.x. Epub 2011 Sep 27.
3
[Frequency of so-called asbestos bodies in human lungs].

本文引用的文献

1
FERRITIN AND APOFERRITIN.铁蛋白与脱铁铁蛋白
Science. 1942 Apr 24;95(2469):439-40. doi: 10.1126/science.95.2469.439.
2
Chromatography of amino acids on sulfonated polystyrene resins.氨基酸在磺化聚苯乙烯树脂上的色谱分析。
J Biol Chem. 1951 Oct;192(2):663-81.
3
Notes on a modification of the Neuman and Logan method for the determination of the hydroxyproline.关于修改用于测定羟脯氨酸的纽曼和洛根方法的注释
Int Arch Arbeitsmed. 1971;28(1):71-82.
4
A histochemical study of the asbestos body coating.石棉小体包被的组织化学研究。
Br J Ind Med. 1972 Apr;29(2):154-9. doi: 10.1136/oem.29.2.154.
5
Histochemical demonstration of hematoidin in the innermost layers of human asbestos body coating.人石棉小体包被最内层血晶素的组织化学显示。
Int Arch Arbeitsmed. 1972;30(4):273-82. doi: 10.1007/BF00544645.
Biochem J. 1960 Jan;74(1):70-1. doi: 10.1042/bj0740070.
4
THE ULTRASTRUCTURE OF ASBESTOS BODIES FROM GUINEA-PIG LUNGS.几内亚猪肺部石棉小体的超微结构
Br J Exp Pathol. 1964 Dec;45(6):634-41.
5
The structure of apoferritin: amino acid composition and end-groups.
J Mol Biol. 1962 Apr;4:251-6. doi: 10.1016/s0022-2836(62)80003-5.
6
The amino acid composition of mammalian collagen and gelatin.哺乳动物胶原蛋白和明胶的氨基酸组成。
Biochem J. 1955 Dec;61(4):589-600. doi: 10.1042/bj0610589.
7
[Amino acid composition in the blood and tissue proteins in man and animals].[人和动物血液及组织蛋白质中的氨基酸组成]
Biochem Z. 1954;325(6):448-58.