石棉小体的蛋白质包被。
The protein coating of asbestos bodies.
作者信息
Blount M, Holt P F, Leach A A
出版信息
Biochem J. 1966 Oct;101(1):204-7. doi: 10.1042/bj1010204.
Abstract
- Asbestos bodies were isolated from human lungs and the amino acid composition of the protein content was determined. 2. The hydroxyproline, glycine, leucine and phenylalanine values indicate that the protein in the coating cannot be principally collagen. 3. Albumin can be adsorbed on chrysotile asbestos as a monolayer but more than a monolayer is adsorbed if iron is also adsorbed. 4. Ferritin is adsorbed on chrysotile to give a thick layer. 5. The amino acid composition and adsorption studies are discussed in the light of the suggestions that the protein coating of asbestos is collagen (Beattie, 1961) or ferritin (Davis, 1964).
摘要
- 从人肺中分离出石棉小体，并测定了其蛋白质含量的氨基酸组成。2. 羟脯氨酸、甘氨酸、亮氨酸和苯丙氨酸的值表明，包被中的蛋白质主要不是胶原蛋白。3. 白蛋白可以单层形式吸附在温石棉上，但如果铁也被吸附，则会吸附超过单层的量。4. 铁蛋白吸附在温石棉上形成厚层。5. 根据石棉的蛋白质包被是胶原蛋白（比蒂，1961年）或铁蛋白（戴维斯，1964年）的观点，对氨基酸组成和吸附研究进行了讨论。
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