Loomis W F, Magasanik B
J Bacteriol. 1967 Apr;93(4):1397-401. doi: 10.1128/jb.93.4.1397-1401.1967.
Growth of Escherichia coli in medium containing glucose, at a concentration insufficient to support full growth, and containing lactose, is diauxic. A mutation in the gene, CR, which determines catabolite repression specific to the lac operon, was found to relieve glucose-lactose but not glucose-maltose diauxie. Furthermore, a high concentration of lactose was shown to overcome diauxie in a CR(+) strain. Studies on the induction of beta-galactosidase by lactose suggested that glucose inhibits induction by 10(-2)m lactose. Preinduction of the lac operon was found to overcome this effect. The ability of glucose to prevent expression of the lac operon by reducing the internal concentration of inducer as well as by catabolite repression is discussed.
大肠杆菌在含有葡萄糖（浓度不足以支持其充分生长）和乳糖的培养基中生长时呈双相生长。发现决定乳糖操纵子特异性分解代谢物阻遏的CR基因发生突变后，可缓解葡萄糖 - 乳糖双相生长，但不能缓解葡萄糖 - 麦芽糖双相生长。此外，高浓度的乳糖可克服CR(+)菌株中的双相生长现象。关于乳糖对β-半乳糖苷酶的诱导研究表明，葡萄糖可抑制10(-2)m乳糖的诱导作用。发现乳糖操纵子的预诱导可克服这种效应。本文讨论了葡萄糖通过降低诱导剂的内部浓度以及通过分解代谢物阻遏来阻止乳糖操纵子表达的能力。
