链霉素敏感性的优势再探讨。
The dominance of streptomycin sensitivity re-examined.
作者信息
Breckenridge L, Gorini L
出版信息
Proc Natl Acad Sci U S A. 1969 Mar;62(3):979-85. doi: 10.1073/pnas.62.3.979.
Abstract
Several aspects of the strA phenotype were studied in strains of Escherichia coli diploid in the strA chromosomal region. It was found that alleles causing different levels of interference with amber suppression can complement each other, the less restrictive effects being predominant. The sensitive strA(+) allele determines two responses to streptomycin: a dominant effect consisting of a sudden, complete, but reversible inhibition of growth, and a recessive effect manifested as cell killing. Both restriction of suppression and inhibition of growth reflect ribosomal involvement in translation.
摘要
在strA染色体区域为二倍体的大肠杆菌菌株中，对strA表型的几个方面进行了研究。发现导致对琥珀抑制有不同程度干扰的等位基因可以相互互补，其中限制作用较小的效应占主导。敏感的strA(+)等位基因决定了对链霉素的两种反应：一种显性效应，表现为生长突然、完全但可逆的抑制；另一种隐性效应，表现为细胞死亡。抑制作用的限制和生长的抑制都反映了核糖体参与翻译过程。
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1
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2
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Proc Natl Acad Sci U S A. 1965 Feb;53(2):451-9. doi: 10.1073/pnas.53.2.451.
3
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Proc Natl Acad Sci U S A. 1964 Jun;51(6):995-1001. doi: 10.1073/pnas.51.6.995.
4
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5
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Science. 1967 Sep 15;157(3794):1314-7. doi: 10.1126/science.157.3794.1314.
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