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兔网织红细胞核糖体的一种可能结构。模型构建练习。

A possible structure of the rabbit reticulocyte ribosome. An exercise in model building.

作者信息

Cox R A, Bonanou S A

出版信息

Biochem J. 1969 Oct;114(4):769-74. doi: 10.1042/bj1140769.

Abstract

It is suggested that the location of each of the diverse ribosomal proteins in the ribosome, or in the ribosomal subparticles in their native or derived forms, is determined by the nucleotide sequence of the 16s and 23-30s RNA moieties, i.e. that the 16s and 23-30s RNA species provide a unique binding site for each species of ribosomal protein. The ways of assembling such a thread into a ribosome-like structure appear limited if the ribosome is largely stabilized by protein-protein interactions. The nucleoprotein thread was built into a structure, having the general features of a hollow cylinder, that is consistent with the known dimensions and properties of the rabbit reticulocyte ribosome. It appears possible to test the model by experiment.

摘要

有人提出,各种核糖体蛋白在核糖体中,或在其天然或衍生形式的核糖体亚颗粒中的位置,是由16S和23 - 30S RNA部分的核苷酸序列决定的,也就是说,16S和23 - 30S RNA种类为每种核糖体蛋白提供了独特的结合位点。如果核糖体主要通过蛋白质 - 蛋白质相互作用而稳定,那么将这样一条链组装成类似核糖体结构的方式似乎是有限的。核蛋白链被构建成一种具有空心圆柱体一般特征的结构,这与兔网织红细胞核糖体的已知尺寸和性质相一致。通过实验来检验该模型似乎是可行的。

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Ribosomes: a common structural feature.核糖体:一个共同的结构特征。
Science. 1963 May 31;140(3570):1000. doi: 10.1126/science.140.3570.1000.
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The size and hydration of rabbit-reticulocyte ribosomes.兔网织红细胞核糖体的大小与水合作用
Biochim Biophys Acta. 1960 Jan 1;37:152-3. doi: 10.1016/0006-3002(60)90093-7.
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