Server A C, Lefkowith J, Braine H, McKhann G M
Ann Neurol. 1979 Sep;6(3):258-61. doi: 10.1002/ana.410060313.
A 58-year-old man developed recurrent episodes of symmetrical motor weakness associated with acroparesthesias and areflexia. The cerebrospinal fluid protein was elevated and nerve conduction velocities were slowed. There was no evidence of systemic disease or toxic exposure, and a diagnosis of chronic relapsing inflammatory polyradiculoneuropathy was made. The patient improved during treatment with corticosteroids, but steroid-induced complications necessitated discontinuance. A recrudescence of symptoms prompted a search for alternative therapy, and plasma exchange was tried. A marked improvement in strength was noted following each course of plasma exchange, suggesting that further similar trials are justified.
一名58岁男性出现与肢端感觉异常和反射消失相关的对称性运动无力反复发作。脑脊液蛋白升高，神经传导速度减慢。没有全身性疾病或中毒暴露的证据，诊断为慢性复发性炎性多发性神经根神经病。患者在使用皮质类固醇治疗期间病情改善，但类固醇引起的并发症需要停药。症状复发促使寻找替代疗法，于是尝试了血浆置换。每次血浆置换疗程后肌力都有明显改善，表明有理由进行进一步类似试验。
