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Studies on methylazoxymethanol: methylation of nucleic acids in the fetal rat brain.

作者信息

Nagata Y, Matsumoto H

出版信息

Proc Soc Exp Biol Med. 1969 Oct;132(1):383-5. doi: 10.3181/00379727-132-34220.

DOI:10.3181/00379727-132-34220
PMID:5344864
Abstract
摘要

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Studies on methylazoxymethanol: methylation of nucleic acids in the fetal rat brain.
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Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.单次经胎盘给予N-甲基-N-亚硝基脲后，各种大鼠胎儿和母体组织DNA中甲基化嘌呤的持续性及子代中的致癌作用。
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Methylation of nucleic acids and urinary excretion of 14 C-labeled 7-methylguanine by rats and man after administration of 4(5)-(3,3-dimethyl-1-triazeno)-imidazole5(4)-carboxomide.给予4(5)-(3,3-二甲基-1-三氮烯)-咪唑5(4)-甲酰胺后，大鼠和人体对核酸的甲基化作用及14C标记的7-甲基鸟嘌呤的尿排泄情况。
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