1-氨基苯并三唑对细胞色素P-450辅基血红素基团的自催化烷基化作用。NN-桥连苯炔-原卟啉IX加合物的分离。
Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.
作者信息
Ortiz de Montellano P R, Mathews J M
出版信息
Biochem J. 1981 Jun 1;195(3):761-4. doi: 10.1042/bj1950761.
Abstract
Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or stimulation of lipid peroxidation. An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyrin IX adduct, appears to be formed by the addition of catalytically generated benzyne to prosthetic haem.
摘要
在1-氨基苯并三唑的催化过程中，肝细胞色素P-450的破坏伴随着微粒体血红素等量的损失，但细胞色素b5并未损失，也没有脂质过氧化的刺激。一种异常卟啉，初步鉴定为NN-桥连苯炔-原卟啉IX加合物，似乎是由催化生成的苯炔加成到辅基血红素上形成的。
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