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1-氨基苯并三唑对细胞色素P-450辅基血红素基团的自催化烷基化作用。NN-桥连苯炔-原卟啉IX加合物的分离。

Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.

作者信息

Ortiz de Montellano P R, Mathews J M

出版信息

Biochem J. 1981 Jun 1;195(3):761-4. doi: 10.1042/bj1950761.

DOI:10.1042/bj1950761
PMID:7316983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162949/
Abstract

Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or stimulation of lipid peroxidation. An abnormal porphyrin, tentatively identified as an NN-bridged benzyne-protoporphyrin IX adduct, appears to be formed by the addition of catalytically generated benzyne to prosthetic haem.

摘要

在1-氨基苯并三唑的催化过程中，肝细胞色素P-450的破坏伴随着微粒体血红素等量的损失，但细胞色素b5并未损失，也没有脂质过氧化的刺激。一种异常卟啉，初步鉴定为NN-桥连苯炔-原卟啉IX加合物，似乎是由催化生成的苯炔加成到辅基血红素上形成的。

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