Villani F, Beretta G, Guindani A
Cancer Chemother Pharmacol. 1979;3(4):249-51. doi: 10.1007/BF00254740.
Systolic time intervals (PEP/LVET ratio) were used for detection of acute variations in myocardial contractility after a single dose of 30, 60, or 75 mg of doxorubicin/m2. This drug induces an acute impairment of left ventricular function (increase in the PEP/LVET ratio) detectable 1 h after doxorubicin injection. The phenomenon appears to be dose-related, with a threshold dose of 30-40 mg/m2. The decrease in myocardial contractility is fully reversible within 24 h, at least after the first dose. This kind of evaluation appears applicable to phase I studies of new anthracycline derivatives.
采用收缩期时间间期（PEP/LVET 比值）来检测单次给予 30、60 或 75mg 多柔比星/平方米后心肌收缩力的急性变化。该药物可导致左心室功能急性受损（PEP/LVET 比值升高），在多柔比星注射后 1 小时即可检测到。这种现象似乎与剂量相关，阈值剂量为 30 - 40mg/平方米。心肌收缩力的降低在 24 小时内可完全恢复，至少在首次给药后是这样。这种评估似乎适用于新蒽环类衍生物的 I 期研究。
