Ogata K, Whiteside L A
Clin Orthop Relat Res. 1979 Nov-Dec(145):273-6.
Hydrogen gas was used as a tracer to identify the barrier to material transfer at bone-cartilage interface in the rabbit knees in vivo. The transfer of hydrogen molecules from subchondral bone to articular cartilage was detected by means of platinum electrodes which were placed in varying depths in articular cartilage and subchondral bone. Hydrogen transfer was obstructed at the osteochondral junction in mature animals, while in immature animals there was no such barrier present in the bone-cartilage interface. The metabolism of articular cartilage in mature animals may be isolated from that of the underlying bone. All layers of the mature cartilage including those in the zone of calcified cartilage can receive nourishment and be maintained from the synovial fluid alone.
氢气被用作示踪剂，以确定兔膝关节体内骨-软骨界面处物质转移的屏障。通过置于关节软骨和软骨下骨不同深度的铂电极检测氢分子从软骨下骨到关节软骨的转移。在成熟动物中，氢转移在骨软骨交界处受阻，而在未成熟动物中，骨-软骨界面不存在这种屏障。成熟动物关节软骨的代谢可能与下方骨骼的代谢相分离。成熟软骨的所有层，包括钙化软骨区域的那些层，都可以仅从滑液中获得营养并得以维持。
