Uchida Y, Nomoto T
Nihon Yakurigaku Zasshi. 1979 Mar;75(2):107-15. doi: 10.1254/fpj.75.107.
Significance of the intercapsular brown adipose tissue (IBAT) in the thermal response to chlorpromazine (CPZ) during acute and chronic cold exposure was studied in rats. Adult male Wistar-Imamichi rats were exposed to 4 degrees C for 1 (cold-exposed) or 30 days (cold-acclimated). Intraperitoneal injection of 10 mg/kg CPZ caused a more marked and lasted hypothermia in acute cold-exposed rats as compared with that seen in control or in cold-acclimatized rats. Hypothermia induced by CPZ was unaffected by removal of IBAT either in control or acute cold-exposed rats. But in cold-acclimated rats, the removal of IBAT potentiated the hypothermia by CPZ. The relative weight of IBAT in cold-acclimated rats was about 3 times heavier than that in control and acute cold-exposed rats. CPZ had no effect on the relative weight of IBAT in all groups examined. Total lipids in IBAT showed no significant changes following CPZ administration in rats of all groups. In acute cold-exposed rats, serum FFA level progressively decreased after CPZ injection. The noradrenaline concentration in IBAT increased after chronic cold exposure and CPZ suppressed this elevation. The results suggest that the thermogenesis related sympathetic activity in the IBAT plays a mediatory role in thermal response to CPZ during cold acclimation.
研究了大鼠急性和慢性冷暴露期间，被膜间棕色脂肪组织（IBAT）在对氯丙嗪（CPZ）热反应中的意义。成年雄性Wistar-Imamichi大鼠暴露于4℃环境1天（冷暴露）或30天（冷适应）。腹腔注射10mg/kg CPZ后，急性冷暴露大鼠出现的体温过低比对照组或冷适应大鼠更明显且持续时间更长。在对照组或急性冷暴露大鼠中，去除IBAT对CPZ诱导的体温过低没有影响。但在冷适应大鼠中，去除IBAT会增强CPZ导致的体温过低。冷适应大鼠中IBAT的相对重量比对照组和急性冷暴露大鼠重约3倍。CPZ对所有检测组中IBAT的相对重量均无影响。所有组大鼠给予CPZ后，IBAT中的总脂质均无显著变化。在急性冷暴露大鼠中，注射CPZ后血清游离脂肪酸（FFA）水平逐渐降低。慢性冷暴露后，IBAT中的去甲肾上腺素浓度升高，而CPZ抑制了这种升高。结果表明，在冷适应过程中，IBAT中与产热相关的交感神经活动在对CPZ的热反应中起介导作用。
