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噬菌体S13中胞嘧啶-5-3H衰变导致的胞嘧啶到胸腺嘧啶的转变。

Cytosine to thymine transitions from decay of cytosine-5-3H in bacteriophage S13.

作者信息

Funk F, Person S

出版信息

Science. 1969 Dec 26;166(3913):1629-31. doi: 10.1126/science.166.3913.1629.

DOI:10.1126/science.166.3913.1629
PMID:5360583
Abstract

Decay of cytosine-5-(3)H incorporated into bacteriophage S13 DNA causes a molectular rearrangement of the cytosine molecutle undergoing the decay. The molecular rearrangement produces a cytosine to thyimine coding change with at efficiency approaching one. Decay of either thymidine-(methyl)-(3)H or cytosine-6-(3)H is less than 1 percent as effective in calusing either cytosine to thymine or thymine to cytosine transitions.

摘要

掺入噬菌体S13 DNA中的胞嘧啶-5-(3)H衰变会导致正在衰变的胞嘧啶分子发生分子重排。这种分子重排产生胞嘧啶到胸腺嘧啶的编码变化,效率接近100%。胸腺嘧啶-(甲基)-(3)H或胞嘧啶-6-(3)H的衰变在导致胞嘧啶到胸腺嘧啶或胸腺嘧啶到胞嘧啶转变方面的效率不到1%。

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