Biagi G L, Barbaro A M, Guerra M C, Hakim G, Solaini G C, Borea P A
J Chromatogr. 1979 Sep 14;177(1):35-9. doi: 10.1016/s0021-9673(00)92597-4.
The RM values of naphthols obtained in a chromatographic system where the stationary phase consisted of a silica gel G layer impregnated with silicone oil are much more closely related to the log P values in an octanol-water system than the RM values determined on polyamide layers. Similarly, the RM values of a series of acetophenones in the silicone system are closely related to their log P values. The equations describing the structure-activity relationship indicate the importance of lipophilic character and halogen substitution in determining the hemolytic activity and the acute toxicity of compounds.
在固定相由浸渍硅油的硅胶G层组成的色谱系统中获得的萘酚的RM值，比在聚酰胺层上测定的RM值与正辛醇-水系统中的log P值关系更为密切。同样，一系列苯乙酮在硅油系统中的RM值与它们的log P值密切相关。描述构效关系的方程表明了亲脂性特征和卤素取代在决定化合物溶血活性和急性毒性方面的重要性。
