Lipson A, Nickoloff E L, Hsu T H, Kasecamp W R, Drew H M, Shakir R, Wagner H N
J Nucl Med. 1979 Nov;20(11):1124-30.
Total serum thyroxine (T4), triiodothyronine (T3), T3 resin uptake (T3U), thyrotrophin (TSH), and reverse T3 (rT3) were measured in 209 healthy adults 20--89 yr old. Mean T4 values for men were stable throughout life, but in females under age 60, T4 values were significantly higher than in older women. Values for T3U in males were significantly higher than in females throughout all decades, although females had a significant increase in T3U after age 60. TSH values increased significantly in females over age 60. Throughout all decades, males had stable TSH levels that were slightly higher than the female results before age 60 and lower thereafter. Mean serum T3 declined similarly for both sexes with increasing age, although not to the extent previously reported. Men had significantly higher mean rT3 values over all decades than females, although female rT3 levels decreased after age 50 whereas males maintained stable values. The physiologic reasons for these findings may be due to sex-related changes in binding proteins and alterations in metabolic clearance rates, production, and degradation of these hormones with increasing age.
对209名年龄在20至89岁的健康成年人测定了血清总甲状腺素（T4）、三碘甲状腺原氨酸（T3）、T3树脂摄取率（T3U）、促甲状腺激素（TSH）和反三碘甲状腺原氨酸（rT3）。男性的平均T4值在一生中保持稳定，但60岁以下女性的T4值显著高于老年女性。在所有年龄段，男性的T3U值均显著高于女性，不过60岁以后女性的T3U值有显著升高。60岁以上女性的TSH值显著升高。在所有年龄段，男性的TSH水平保持稳定，60岁前略高于女性，60岁后低于女性。随着年龄增长，男性和女性的平均血清T3均以相似的幅度下降，尽管下降幅度不及先前报道的程度。在所有年龄段，男性的平均rT3值均显著高于女性，不过女性的rT3水平在50岁后下降，而男性保持稳定。这些发现的生理原因可能与结合蛋白的性别相关变化以及随着年龄增长这些激素的代谢清除率、产生和降解的改变有关。
