Iwatsuki K, Hashimoto K
Jpn J Pharmacol. 1979 Apr;29(2):187-90. doi: 10.1254/jjp.29.187.
Effect of 5-dimethyldithiocarbamylpicolinic acid (YP-279), a dopamine beta-hydroxylase inhibitor, on the secretion of pancreatic juice induced by dopamine was investigated in preparations of the isolated blood-perfused canine pancreas. Either a single injection (300 micrograms) or an infusion (100 micrograms/min) of YP-279 intra-arterially (i.a.) caused no change in the outflow of the pancreatic juice, but the secretagogue effect of dopamine (1-10 micrograms, i.a.) was enhanced by the infusion of YP-279 (100 micrograms/min, i.a.) for 60 min. The previous conclusion obtained with fusaric acid was confirmed as follows; the dopamine beta-hydroxylase activity controls the dopaminergic mechanism of the pancreatic secretion.
在离体血液灌注犬胰腺制备物中，研究了多巴胺β-羟化酶抑制剂5-二甲基二硫代氨基甲酰吡啶酸（YP - 279）对多巴胺诱导的胰液分泌的影响。动脉内单次注射（300微克）或输注（100微克/分钟）YP - 279不会引起胰液流出量的变化，但在输注YP - 279（100微克/分钟，动脉内）60分钟后，多巴胺（1 - 10微克，动脉内）的促分泌作用增强。用富马酸获得的先前结论得到如下证实：多巴胺β-羟化酶活性控制胰腺分泌的多巴胺能机制。
