Iwatsuki K, Iijima F, Chiba S
Arch Int Pharmacodyn Ther. 1983 Feb;261(2):328-34.
The effects of hydergine on the secretion of pancreatic juice in the dog were investigated in preparations of the isolated, blood-perfused pancreas, and compared with those of secretin and dopamine. Hydergine (30-300 micrograms) injected intra-arterially caused dose-dependent increases in the secretion of pancreatic juice after a delay of a few min. The secretory activity of 300 micrograms of hydergine was approximately equal to that of 0.05 units of secretin and 2 micrograms of dopamine. Secretory responses to hydergine were inhibited by treatment with sulpiride, but not inhibited by phentolamine, propranolol, atropine or metiamide. The concentration of bicarbonate in the pancreatic juice induced by hydergine was increased in a dose-dependent manner. However, the protein concentration was scarcely changed. These secretory actions were analogous to those of dopamine. From these results, it is concluded that hydergine mainly stimulates pancreatic secretion by acting on dopaminergic receptors of the dog pancreas.
在离体、血液灌注的犬胰腺标本中研究了喜得镇对犬胰液分泌的影响，并与促胰液素和多巴胺的作用进行了比较。动脉内注射喜得镇（30 - 300微克），数分钟后可引起胰液分泌呈剂量依赖性增加。300微克喜得镇的分泌活性约等于0.05单位促胰液素和2微克多巴胺的分泌活性。舒必利处理可抑制对喜得镇的分泌反应，但酚妥拉明、普萘洛尔、阿托品或甲硫咪胺处理则不抑制。喜得镇诱导的胰液中碳酸氢盐浓度呈剂量依赖性增加。然而，蛋白质浓度几乎没有变化。这些分泌作用与多巴胺的作用相似。从这些结果可以得出结论，喜得镇主要通过作用于犬胰腺的多巴胺能受体来刺激胰腺分泌。
