Baker M R, Davies J A, Tate G M, Lee M R
Postgrad Med J. 1979 Oct;55(648):757-61. doi: 10.1136/pgmj.55.648.757.
Two cases of the nephrotic syndrome with an apparently identical defect of blood coagulation, discovered during preparation for renal biopsy are described. Plasma from both patients showed prolongation of thrombin and kaolin cephalin times which was probably due to abnormally slow polymerization of fibrin monomer. Corticosteroid therapy reversed the abnormal times in one case. One of the patients showed seasonal relapses which occurred in relation to episodes of hay fever associated with allergy to grass pollen. The other patient showed some similar features, but on renal biopsy was found to have proliferative glomerulonephritis.
本文描述了两例在准备肾活检时发现的具有明显相同凝血缺陷的肾病综合征病例。两名患者的血浆均显示凝血酶和高岭土部分凝血活酶时间延长，这可能是由于纤维蛋白单体异常缓慢聚合所致。皮质类固醇治疗使其中一例患者的异常时间恢复正常。其中一名患者出现季节性复发，与对草花粉过敏相关的花粉热发作有关。另一名患者也有一些类似特征，但肾活检发现患有增殖性肾小球肾炎。
