Edgar S A, Flanagan C
Poult Sci. 1979 Nov;58(6):1469-75. doi: 10.3382/ps.0581469.
The efficacy of Stenorol (halofunginone) was tested against six species of chicken Eimeria in a series of four battery experiments utilizing 3- to 4 1/2-week-old Cobb color-sexed broiler chickens. There were five replicates of eight chickens per replicate for each treatment of an experiment or a total of 1080 birds used in the study. The isolates were predominantly E. tenella, E. maxima, E. acevulina, E. necatrix, E. brunetti, or E. mivati and had previously been proven partially to totally resistant to several commercially available anticoccidial drugs. Halofunginone, at 3 ppm in the ration, was highly effective (P less than .01) against all six isolates as measured by weight gain at D+6 or +7and D+12 or +14 postinoculation; feed efficiency at D-2 to D+12 or +14; morbidity; mortality; dropping score; lesion score (D+6 or +7); and oocyst production during 4 or 5 days postinoculation (D = day of inoculation). The drug was not as effective against E. acervulina as against the other species, and increasing halofuginone to 4 ppm failed to improve activity of the drug signif;cantly against this isolate. However, 3 ppm of drug was effective against two other isolates of E. acervulina (from Alabama and Mississippi); 4 ppm was quite effective (P less than .01) in reducing dropping and lesion scores, but not significantly better than 3 ppm as measureed by other parameters. No relapse occurred after drug withdrawal and halofuginone was found to be cidal rather than static.
在一系列四项层架式实验中，使用3至4.5周龄的科宝（Cobb）羽色自别雌雄肉鸡，测试了Stenorol（卤夫酮）对六种鸡艾美耳球虫的疗效。每项实验的每种处理有五个重复，每个重复八只鸡，该研究共使用了1080只鸡。分离株主要是柔嫩艾美耳球虫、巨型艾美耳球虫、堆型艾美耳球虫、毒害艾美耳球虫、布氏艾美耳球虫或米氏艾美耳球虫，先前已证明它们对几种市售抗球虫药部分至完全耐药。日粮中添加3 ppm的卤夫酮，通过接种后第6或7天、第12或14天的体重增加；接种前2天至接种后第12或14天的饲料效率；发病率；死亡率；粪便评分；病变评分（接种后第6或7天）；以及接种后4或5天的卵囊产量（D =接种日）来衡量，对所有六种分离株都非常有效（P小于0.01）。该药物对堆型艾美耳球虫的效果不如对其他种类球虫的效果，将卤夫酮增加到4 ppm并不能显著提高该药物对这种分离株的活性。然而，3 ppm的药物对另外两种堆型艾美耳球虫分离株（来自阿拉巴马州和密西西比州）有效；4 ppm在降低粪便和病变评分方面非常有效（P小于0.01），但按其他参数衡量并不比3 ppm显著更好。停药后未发生复发，并且发现卤夫酮具有杀灭作用而非抑制作用。
