Kelly J, Grossman S P
Pharmacol Biochem Behav. 1979 Dec;11(6):647-52. doi: 10.1016/0091-3057(79)90257-0.
Microinjections of various compounds into the paraventricular hypothalamic nucleus (PVH) were made and the effects on feeding observed. During the light phase of the lighting cycle, injections of 0.3 microliter of muscimol (100 ng) and flurazepam diHCl (20 micrograms) increased feeding. Similar injections of glycine (500 ng) did not influence feeding during the light phase. During the dark phase, 0.3 microliter injections of bicuculline methiodide (30 ng) and picrotoxin (160 ng) suppressed feeding. Similar i-jections of carbachol increased drinking during the dark phase. Injections of strychnine during this phase were without effect. Tilt box activity levels were not altered by injection of picrotoxin (160 ng) into the PVH.
将各种化合物微量注射到下丘脑室旁核（PVH）中，并观察其对进食的影响。在光照周期的亮期，注射0.3微升蝇蕈醇（100纳克）和二盐酸氟西泮（20微克）会增加进食量。在亮期，类似剂量的甘氨酸（500纳克）注射对进食没有影响。在暗期，注射0.3微升甲碘化荷包牡丹碱（30纳克）和苦味毒（160纳克）会抑制进食。在暗期，类似剂量的卡巴胆碱注射会增加饮水。在此阶段注射士的宁没有效果。向PVH注射苦味毒（160纳克）不会改变倾斜箱活动水平。
