Kastin A J, Jemison M T, Coy D H
Pharmacol Biochem Behav. 1979 Dec;11(6):713-6. doi: 10.1016/0091-3057(79)90268-5.
Several analogues of Met-enkephalin and beta-endorphin were tested for their analgesic properties after systemic injection. The latencies of mice to flick their tails away from a source of heat revealed that analogues of the opiate peptides can cause analgesia when injected by this route. In particular, compounds specifically designed to be more lipophilic or to possess additional binding sites were shown to be potent analgesic after peripheral administration.
对甲硫氨酸脑啡肽和β-内啡肽的几种类似物进行了全身注射后的镇痛特性测试。小鼠将尾巴从热源移开的潜伏期表明，阿片肽类似物经此途径注射时可引起镇痛作用。特别是，专门设计为更具亲脂性或具有额外结合位点的化合物在外周给药后显示出强效镇痛作用。
