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胃泌素对人食管下括约肌的作用。

Action of gastrin on the lower oesophageal sphincter in man.

作者信息

Giles G R, Mason M C, Humphries C, Clark C G

出版信息

Gut. 1969 Sep;10(9):730-4. doi: 10.1136/gut.10.9.730.

DOI:10.1136/gut.10.9.730
PMID:5386630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1552975/
Abstract

Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appears to be independent of the secretory stimulus.

摘要

猪胃泌素和合成胃泌素均可刺激贲门括约肌，使其张力增加，并增强抗反流能力。内源性胃泌素也有类似作用，且胃泌素还能刺激胃酸分泌，而胃酸也被发现可增加括约肌的抗反流能力，但胃泌素的作用似乎与分泌刺激无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58b/1552975/3f062ecc49e9/gut00699-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58b/1552975/26a946f7d64b/gut00699-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58b/1552975/3f062ecc49e9/gut00699-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58b/1552975/26a946f7d64b/gut00699-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c58b/1552975/3f062ecc49e9/gut00699-0049-a.jpg

相似文献

1
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本文引用的文献

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GASTRO-OESOPHAGEAL REFLUX AFTER PARTIAL GASTRECTOMY.胃部分切除术后的胃食管反流
Br Med J. 1964 Nov 14;2(5419):1233-4. doi: 10.1136/bmj.2.5419.1233.
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THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA.从猪胃窦黏膜中提取的两种胃泌素的组成与特性
Gut. 1964 Apr;5(2):103-14.
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Oesophageal stricture after partial gastrectomy.胃部分切除术后食管狭窄
英国食管外科手术史。
Thorax. 1982 Nov;37(11):795-802. doi: 10.1136/thx.37.11.795.
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Reflux and hernia.反流与疝。
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Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin.人下食管括约肌功能的激素调节：胃泌素与促胰液素的相互作用。
J Clin Invest. 1971 Feb;50(2):449-54. doi: 10.1172/JCI106512.
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Smoking and gastro-oesophageal reflux.吸烟与胃食管反流
Br Med J. 1972 Sep 30;3(5830):793-5. doi: 10.1136/bmj.3.5830.793.
8
A test of gastroesophageal sphincter competence. The common cavity test.胃食管括约肌功能测试。共同腔测试。
Am J Dig Dis. 1972 May;17(5):415-21. doi: 10.1007/BF02231293.
9
The genesis of lower esophageal sphincter pressure: its identification through the use of gastrin antiserum.下食管括约肌压力的起源：通过使用胃泌素抗血清对其进行识别。
J Clin Invest. 1972 Mar;51(3):522-9. doi: 10.1172/JCI106840.
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The oesophagus.食管。
Gut. 1971 Nov;12(11):948-56. doi: 10.1136/gut.12.11.948.
Br J Surg. 1961 Nov;49:307-13. doi: 10.1002/bjs.18004921515.
4
Oesophageal strictures after gastric surgery and naso-gastric intubation.胃手术后及鼻胃插管后的食管狭窄
Br Med J. 1958 Oct 4;2(5100):817-9. doi: 10.1136/bmj.2.5100.817.
5
Analysis of the motor effects of gastrin and pentagastrin on the human alimentary tract in vitro.胃泌素和五肽胃泌素对人体消化道运动作用的体外分析。
Gut. 1967 Oct;8(5):470-4. doi: 10.1136/gut.8.5.470.
6
Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin.人体消化道对近最大剂量五肽胃泌素输注的运动反应。
Gut. 1967 Oct;8(5):463-9. doi: 10.1136/gut.8.5.463.
7
Comparison of the effects of a gastrin extract and a synthetic pentapeptide on gastrointestinal motility in the cat.胃泌素提取物和合成五肽对猫胃肠道运动影响的比较。
Gut. 1967 Jun;8(3):242-8. doi: 10.1136/gut.8.3.242.
8
Gastric secretion stimulated by meat extract in man.肉提取物对人体胃液分泌的刺激作用。
Scand J Gastroenterol. 1966;1(3):159-66. doi: 10.1080/00365521.1966.11800629.
9
Effect of oesophageal perfusion with acid on basal gastric secretion.食管灌注酸对基础胃分泌的影响。
Gut. 1968 Feb;9(1):52-6. doi: 10.1136/gut.9.1.52.
10
Effects of gastrin and its analogues on isolated smooth muscles.胃泌素及其类似物对离体平滑肌的作用。
Nature. 1967 Apr 1;214(5083):105-7. doi: 10.1038/214105a0.