Murphy J C, Watson E S, Wirth P W, Skierkowski P, Folk R M, Peck G
Toxicology. 1979 Oct;14(2):117-30. doi: 10.1016/0300-483x(79)90058-1.
Of 30 antineoplastic agents studied for their primary irritation potential in rabbits, 9 showed some potential for irritation. Five of these 9 agents produced a significant dermal irritation. None of the irritation observed was considered to be irreversible skin damage. The study further showed a strong correlation between irritation observed by the Draize method and acute inflammation evaluated histopathologically. There was a tendency toward increased epidermal thickness of irritated skin sites. None of the agents produced gross or microscopically visible lesions in the internal organs observed.
