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氟苯达唑对彭亨布鲁线虫的驱虫作用。

The anthelmintic effects of flubendazole on Brugia pahangi.

作者信息

Denham D A, Samad R, Cho S Y, Suswillo R R, Skippins S C

出版信息

Trans R Soc Trop Med Hyg. 1979;73(6):673-6. doi: 10.1016/0035-9203(79)90018-x.

DOI:10.1016/0035-9203(79)90018-x
PMID:538808
Abstract

The anthelmintic effects of flubendazole (methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl] carbamate) (Janssen Pharmaceutica) were evaluated in jirds (Meriones unguiculatus) and cats (Felis cattus) infected with Brugia pahangi. Flubendazole was macrofilaricidal at 5 x 2.5 mg/kg and 1 x 25 mg/kg in jirds and 1 x 100 mg/kg in cats when administered by subcutaneous injection. It also killed developing larvae in jirds. It was not microfilaricidal.

摘要

对感染彭亨布鲁线虫的沙鼠(长爪沙鼠)和猫(家猫)评估了氟苯达唑([5-(4-氟苯甲酰基)-1-H-苯并咪唑-2-基]氨基甲酸甲酯)(杨森制药公司)的驱虫效果。通过皮下注射给药时,氟苯达唑在沙鼠中剂量为5×2.5mg/kg和1×25mg/kg、在猫中剂量为1×100mg/kg时具有杀成虫作用。它还能杀死沙鼠体内发育中的幼虫。它不具有杀微丝蚴作用。

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