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氟苯达唑对移植到沙鼠腹腔内的成年彭亨丝虫的化学预防活性。

Chemoprophylactic activity of flubendazole against adult Brugia pahangi transplanted into the peritoneal cavity of jirds.

作者信息

Denham D A, Brandt E

出版信息

J Parasitol. 1980 Dec;66(6):933-4.

PMID:7218115
Abstract

Jirds were treated by the subcutaneous injection of 100 mg flubendazole per kilogram. They were infected subsequently by the implantation of adult Brugia pahangi intraperitoneally at different times. No adult worms survived in jirds treated 9 wk before infection. Thereafter, increasing numbers of adult worms survived so tht by 21 wk there were almost as many worms in the treated jirds as in untreated controls.

摘要

沙鼠通过皮下注射每千克100毫克氟苯达唑进行治疗。随后在不同时间通过腹腔内植入彭亨丝虫成虫使其感染。在感染前9周接受治疗的沙鼠中没有成虫存活。此后,存活的成虫数量不断增加,以至于到21周时,接受治疗的沙鼠体内的蠕虫数量几乎与未治疗的对照组一样多。

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