彭亨布鲁线虫的研究。13. 化合物F151（弗里德海姆）、HOE 33258（赫斯特）及其反应产物的驱虫效果。
Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product.
作者信息
Denham D A, Suswillo R R, Rogers R, McGreevy P B, Andrews B J
出版信息
J Helminthol. 1976 Dec;50(4):243-50. doi: 10.1017/s0022149x00026663.
PMID:64486
Abstract
F151 was a potent filaricide against adult Brugia pahangi in cats and jirds. HOE 33258 did not kill adult worms in cats but had a marginal effect on adult worms in the peritoneal cavity of jirds. It was not immediately microfilaricidal in cats but the microfilarial counts of treated cats fell within a few weeks of treatment. The reaction product, or mixture, of these two compounds (V5851 = E) was strongly macrofilaricidal in cats and jirds.
摘要
F151对猫和沙鼠体内的成年彭亨布鲁线虫具有强效杀丝虫作用。HOE 33258对猫体内的成虫无致死作用，但对沙鼠腹腔内的成虫有轻微作用。它对猫没有立即产生杀微丝蚴作用，但治疗后的猫在几周内微丝蚴数量下降。这两种化合物的反应产物或混合物（V5851 = E）对猫和沙鼠具有强烈的杀成虫作用。
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