Pearce L A, Schanberg S M
Science. 1969 Dec 5;166(3910):1301-3. doi: 10.1126/science.166.3910.1301.
Histamine concentration in fetal rat brain is high at 17 days gestation but decreases sharply just before birth. Values subsequently increase to a maximum postnatal concentration 5 to 10 days after birth, and then steadily decline to low adult values by time of weaning. Spermidine follows a pattern similar to that of histamine but with a 24- to 48-hour lag. The developmental pattern for histamine in the central nervous system is different from that for other neural amines. It appears that the marked fetal and neonatal changes in brain histamine correlate best with periods of rapid cell proliferation and growth during brain maturation.
妊娠17天时，胎鼠脑中组胺浓度较高，但在出生前急剧下降。随后，其值在出生后5至10天升至出生后最高浓度，然后在断奶时稳步降至较低的成年值。亚精胺的变化模式与组胺相似，但有24至48小时的延迟。中枢神经系统中组胺的发育模式与其他神经胺不同。看来，脑组胺在胎儿期和新生儿期的显著变化与脑成熟过程中细胞快速增殖和生长的时期最为相关。
