Morgenstern C, Laskawi R, Juhn S K
Arch Otorhinolaryngol. 1982;234(3):313-20. doi: 10.1007/BF00464336.
Nicergolin is used in the treatment of tinnitus, cerebral insufficiency, and sensorineural hearing loss. An increase of cerebral blood flow was observed after i.v. injection of Nicergolin (0.1 mg/kg). The effect of this drug on the inner ear was studied by measuring the DC potential and K+ activity in the endolymph. A rapid fall of the DC potential and hypocapnea were observed after the injection of Nicergolin (0.2 mg/kg). An increase of expiratory PCO2 (10-20 mm Hg) was also observed. Arteficial respiration with pure oxygen prevented the fall of the DC potential. The present investigation demonstrates that this drug primarily acts on the respiratory center with secondary PCO2 increase in the blood which then causes the dilatation of cerebral vessels. The fall of the DC potential after the injection of Nicergolin appears to be caused by hypoxia and not by direct effect on the inner ear.
尼麦角林用于治疗耳鸣、脑供血不足和感音神经性听力损失。静脉注射尼麦角林（0.1mg/kg）后，观察到脑血流量增加。通过测量内淋巴中的直流电位和钾离子活性，研究了该药物对内耳的影响。注射尼麦角林（0.2mg/kg）后，观察到直流电位迅速下降和低碳酸血症。呼气末二氧化碳分压也升高了（10 - 20mmHg）。纯氧人工呼吸可防止直流电位下降。本研究表明，该药物主要作用于呼吸中枢，导致血液中二氧化碳分压继发性升高，进而引起脑血管扩张。注射尼麦角林后直流电位下降似乎是由缺氧引起的，而非对内耳的直接作用。
