甲胎蛋白、白蛋白、血红素结合蛋白和触珠蛋白的生物合成与胎鼠肝细胞培养物生长状态的关系。
Relationship of the biosynthesis of alpha-fetoprotein, albumin, hemopexin, and haptoglobin to the growth state of fetal rat hepatocyte cultures.
作者信息
Sell S, Skelly H, Leffert H L, Muller-Eberhard U, Kida S
出版信息
Ann N Y Acad Sci. 1975 Aug 22;259:45-58. doi: 10.1111/j.1749-6632.1975.tb25401.x.
Abstract
AFP and albumin are produced by arginine-synthesizing fetal rat hepatocytes in vitro. AFP and hemopexin production are coupled to hepatocellular proliferation, whereas albumin and haptoglobin production are not. During the cell cycle, AFP is synthesized prior to S and released prior to M. AFP may play a role in regulation of hepatocellular growth through estradiol binding and modulation of the intracellular concentration of lipoprotein (VLDL).
摘要
甲胎蛋白（AFP）和白蛋白在体外由精氨酸合成的胎鼠肝细胞产生。AFP和血红素结合蛋白的产生与肝细胞增殖相关联，而白蛋白和触珠蛋白的产生则不然。在细胞周期中，AFP在S期之前合成，在M期之前释放。AFP可能通过雌二醇结合以及调节细胞内脂蛋白（极低密度脂蛋白，VLDL）浓度来参与肝细胞生长的调节。
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