蛙骨骼肌收缩钙激活的细胞内位点。
The intracellular site of calcium activaton of contraction in frog skeletal muscle.
作者信息
Winegrad S
出版信息
J Gen Physiol. 1970 Jan;55(1):77-88. doi: 10.1085/jgp.55.1.77.
Abstract
Radioautography has been used to localize (45)Ca in isotopically labeled frog skeletal muscle fibers which had been quickly frozen during a maintained tetanus, a declining tetanus, or during the period immediately following a tetanus or a contracture. During a tetanus almost all of the myofibrillar (45)Ca is localized in the region of the sarcomere occupied by the thin filaments. The amount varies with the tension being developed by the muscle. The movement of calcium within the reticulum from the tubular portion to the terminal cisternae during the posttetanic period has a half-time of about 9 sec at room temperature and a Q(10) of about 1.7. Repolarization is not necessary for this movement. Evidence is given to support the notion that most calcium efflux from the cell occurs from the terminal cisternae into the transverse tubules.
摘要
放射自显影术已被用于在同位素标记的青蛙骨骼肌纤维中定位（45）钙，这些纤维在持续强直收缩、递减强直收缩期间，或在强直收缩或挛缩后的紧接着的时期内被快速冷冻。在强直收缩期间，几乎所有肌原纤维中的（45）钙都定位在细肌丝占据的肌节区域。其含量随肌肉产生的张力而变化。在强直收缩后的时期，钙在肌质网内从管状部分向终池的移动在室温下的半衰期约为9秒，温度系数（Q10）约为1.7。这种移动不需要复极化。有证据支持这样的观点，即细胞内的大多数钙外流发生在终池进入横管。
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