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通过诱导部分耐受性抑制迟发型超敏反应的体外研究。

In vitro studies of the suppression of delayed hypersensitivity by the induction of partial tolerance.

作者信息

Borel Y, David J R

出版信息

J Exp Med. 1970 Mar 1;131(3):603-10. doi: 10.1084/jem.131.3.603.

DOI:10.1084/jem.131.3.603
PMID:5413331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138816/
Abstract

Suppression of delayed hypersensitivity in vivo is correlated in vitro with the absence of macrophage migration inhibition in the presence of the antigen used to induce partial tolerance. The suppression of delayed hypersensitivity is antigen-specific in vivo as well as in vitro. The lymphocytes, and not the macrophages, are the cells involved in the induction of tolerance in terms of delayed hypersensitivity which is characterized by an absence of migratory factor activity.

摘要

体内迟发型超敏反应的抑制在体外与在用于诱导部分耐受性的抗原存在下巨噬细胞迁移抑制的缺失相关。迟发型超敏反应的抑制在体内和体外都是抗原特异性的。就以迁移因子活性缺失为特征的迟发型超敏反应而言，淋巴细胞而非巨噬细胞是参与耐受性诱导的细胞。

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本文引用的文献

1
IMMUNOLOGIC UNRESPONSIVENESS IN THE ADULT GUINEA PIG. I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS.成年豚鼠的免疫无反应性。I. 对蛋白质抗原的迟发型超敏反应和抗体形成的抑制
J Immunol. 1965 Jun;94:966-75.
2
DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS.体外迟发型超敏反应。I. 抗原对细胞迁移抑制作用的特异性。
J Immunol. 1964 Aug;93:264-73.
3
RECOGNITION OF FOREIGNNESS IN IMMUNE AND TOLERANT ANIMALS.免疫和耐受动物中异物的识别
Nature. 1964 Feb 8;201:580-2. doi: 10.1038/201580a0.
4
IMMUNOLOGICAL SPECIFICITY OF THE SECONDARY RESPONSE WITH DINITROPHENYLATED PROTEINS.二硝基苯基化蛋白质二次反应的免疫特异性
Proc Soc Exp Biol Med. 1963 Oct;114:72-6. doi: 10.3181/00379727-114-28589.
5
Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis.豚鼠7S抗体的特性。III. 补体结合和溶血相关抗体的鉴定。
J Exp Med. 1963 Jun 1;117(6):965-81. doi: 10.1084/jem.117.6.965.
6
In vitro cell migration as a model for delayed hypersensitivity.体外细胞迁移作为迟发型超敏反应的模型。
Proc Soc Exp Biol Med. 1962 Nov;111:514-21. doi: 10.3181/00379727-111-27841.
7
Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.低分子量物质超敏反应的研究。III. 2,4-二硝基苯基作为沉淀素反应中的一个决定簇
J Immunol. 1954 Nov;73(5):296-308.
8
Dissociation of immune responses by the induction of partial unresponsiveness. Relationship of PCA and complement-fixing antibody formation to the suppression of delayed hypersensitivity.通过诱导部分无反应性实现免疫反应的解离。被动皮肤过敏反应（PCA）和补体结合抗体形成与迟发型超敏反应抑制的关系。
J Immunol. 1967 May;98(5):881-7.
9
Macrophages from tolerant rabbits as mediators of a specific immunological response in vitro.来自耐受兔的巨噬细胞作为体外特异性免疫反应的介质。
Immunology. 1967 Feb;12(2):159-63.
10
Immunochemical studies on the specificity of cellular hypersensitivity. The in vitro inhibition of peritoneal exudate cell migration by cehmically defined antigens.细胞超敏反应特异性的免疫化学研究。化学确定的抗原对腹腔渗出细胞迁移的体外抑制作用。
J Exp Med. 1968 Dec 1;128(6):1451-9. doi: 10.1084/jem.128.6.1451.