来自耐受兔的巨噬细胞作为体外特异性免疫反应的介质。
Macrophages from tolerant rabbits as mediators of a specific immunological response in vitro.
作者信息
Harris G
出版信息
Immunology. 1967 Feb;12(2):159-63.
Abstract
An attempt has been made to evaluate the role of macrophages from rabbits rendered tolerant in neonatal life to BGG in the immune response. The results show that macrophages from a tolerant rabbit took up the antigen to which it was tolerant and stimulated a specific response in the rate of DNA synthesis by spleen cells from an immunized animal. Whatever the role macrophages play in the immune response, no obvious defect of recognition of the antigenic molecules was demonstrated and this would agree with experiments using rats and a bacterial antigen (Nossal and Ada, 1964), where tolerant animals were able to recognize antigen in a manner characteristic of immune animals.
摘要
人们试图评估新生期对牛血清白蛋白（BGG）产生耐受的家兔体内巨噬细胞在免疫反应中的作用。结果显示，来自耐受家兔的巨噬细胞摄取了其耐受的抗原，并刺激了免疫动物脾细胞DNA合成速率的特异性反应。无论巨噬细胞在免疫反应中发挥何种作用，均未显示出对抗原分子识别的明显缺陷，这与使用大鼠和一种细菌抗原的实验结果一致（诺萨尔和艾达，1964年），在该实验中，耐受动物能够以免疫动物特有的方式识别抗原。
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Immunology. 1967 Feb;12(2):159-63.
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