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头孢菌素活性的回归曲线分析。

Regression curve analysis of cephalosporin activity.

作者信息

Washington J A, Yu P K

出版信息

Appl Microbiol. 1970 Apr;19(4):589-93. doi: 10.1128/am.19.4.589-593.1970.

DOI:10.1128/am.19.4.589-593.1970
PMID:5418940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376744/
Abstract

Regression lines were calculated for cephalothin, cephalexin, and cephaloridine by relating zone diameters of inhibition to minimal inhibitory concentrations (MIC) obtained in Mueller-Hinton agar and in Trypticase Soy Agar. A regression line was calculated for cephaloglycin by obtaining MIC values in Trypticase Soy Agar at pH 6.6. Regression lines calculated from MIC values in Mueller-Hinton agar were practically superimposable on those based on MIC values in Trypticase Soy Agar. Organisms susceptible by disc testing to cephalothin were usually susceptible to cephalexin and cephaloridine.

摘要

通过将在穆勒-欣顿琼脂和胰蛋白胨大豆琼脂中获得的抑菌圈直径与最低抑菌浓度（MIC）相关联，计算了头孢噻吩、头孢氨苄和头孢啶的回归线。通过在pH 6.6的胰蛋白胨大豆琼脂中获得MIC值，计算了头孢甘氨酸的回归线。从穆勒-欣顿琼脂中的MIC值计算出的回归线实际上与基于胰蛋白胨大豆琼脂中的MIC值的回归线重叠。通过纸片法检测对头孢噻吩敏感的菌株通常对头孢氨苄和头孢啶敏感。

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1
Regression curve analysis of cephalosporin activity.头孢菌素活性的回归曲线分析。
Appl Microbiol. 1970 Apr;19(4):589-93. doi: 10.1128/am.19.4.589-593.1970.
2
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Antimicrob Agents Chemother. 1976 Sep;10(3):507-10. doi: 10.1128/AAC.10.3.507.

引用本文的文献

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Cefazolin as a predictor of urinary cephalosporin activity in indicated Enterobacterales.头孢唑林对有指征的肠杆菌科细菌尿液头孢菌素活性的预测作用。
J Clin Microbiol. 2024 Apr 10;62(4):e0078821. doi: 10.1128/jcm.00788-21. Epub 2024 Mar 8.
2
Influence of growth medium on the in vitro activities of second- and third-generation cephalosporins against Streptococcus faecalis.生长培养基对第二代和第三代头孢菌素体外抗粪肠球菌活性的影响。
J Clin Microbiol. 1984 Sep;20(3):561-7. doi: 10.1128/jcm.20.3.561-567.1984.
3
Intraocular penetration of cephaloridine.头孢菌素的眼内渗透性。
Br J Ophthalmol. 1972 Jul;56(7):531-6. doi: 10.1136/bjo.56.7.531.

本文引用的文献

1
LABORATORY AND CLINICAL EVALUATION OF A NEW ANTIBIOTIC--CEPHALOTHIN.一种新型抗生素——头孢噻吩的实验室及临床评估
Ann Intern Med. 1965 Aug;63:199-211. doi: 10.7326/0003-4819-63-2-199.
2
CEPHALOTHIN: ACTIVITY IN VITRO, ABSORPTION AND EXCRETION IN NORMAL SUBJECTS AND CLINICAL OBSERVATIONS IN 40 PATIENTS.头孢噻吩：体外活性、正常受试者的吸收与排泄以及40例患者的临床观察
Am J Med Sci. 1964 Dec;248:640-56.
3
CEPHALOTHIN--A NEW ANTIBIOTIC. PRELIMINARY CLINICAL AND LABORATORY STUDIES.头孢噻吩——一种新型抗生素。初步临床及实验室研究。
JAMA. 1964 Sep 14;189:823-8.
4
The use of a bile-aesculin medium and of Maxted's technique of Lancefield grouping in the identification of enterococci (group D streptococci).在肠球菌（D群链球菌）鉴定中使用胆汁七叶苷培养基及马克斯泰德氏兰斯菲尔德分组技术。
J Clin Pathol. 1954 May;7(2):160-3. doi: 10.1136/jcp.7.2.160.
5
Factors influencing in vitro susceptibility to the cephalosporins and clinical trial of an oral cephalosporin, cephaloglycin.影响头孢菌素体外敏感性的因素及口服头孢菌素头孢甘氨酸的临床试验
Antimicrob Agents Chemother (Bethesda). 1966;6:82-7.
6
In vitro and in vivo laboratory comparison of cephalothin and desacetylcephalothin.头孢噻吩与去乙酰头孢噻吩的体外和体内实验室比较
Antimicrob Agents Chemother (Bethesda). 1965;5:870-5.
7
Influence of antibiotic stability on the results of in vitro testing procedures.抗生素稳定性对体外检测程序结果的影响。
J Bacteriol. 1964 May;87(5):1162-70. doi: 10.1128/jb.87.5.1162-1170.1964.
8
Delineation of the differences of various bacterial susceptibility tests with cephalexin.头孢氨苄对各种细菌药敏试验差异的描述。
Antimicrob Agents Chemother (Bethesda). 1968;8:435-41.
9
Clinical evaluation of cephaloridine.
Arch Intern Med. 1968 Jan;121(1):24-38.
10
Cephaloridine activity in vitro and absorption and urinary excretion in normal young men.
Am J Med Sci. 1966 Apr;251(4):433-48.