Alston W C
J Clin Pathol. 1970 Apr;23(3):249-53. doi: 10.1136/jcp.23.3.249.
A young man, who was admitted to hospital acutely ill following the ingestion of half a mouthful of carbon tetrachloride, was investigated for the degree and duration of hepatic and renal damage, using various tests of function. On the basis of the serum bilirubin and enzyme activities, the acute hepatic damage had subsided after 15 days from the time of the accident, but the serum albumin and total proteins returned to normal only after a considerably longer time interval (between 33 and 129 days). There was no evidence of residual hepatic damage after this time. Acute renal damage reached a maximum about a week after the accident, and recovery of function in respect of the kidneys' power to reabsorb sodium and chloride and to secrete potassium and acid recovered almost completely after three weeks. However, the power of the kidneys to reabsorb water, ie, to produce a concentrated urine, approached normal only after 139 days. Residual renal damage was not evident after this time interval as indicated by the clearance values for creatinine and inorganic phosphate. The significance of the results is discussed.
一名年轻男子在摄入半口四氯化碳后病情危急被送入医院，通过各种功能测试对其肝脏和肾脏损伤的程度及持续时间进行了调查。根据血清胆红素和酶活性，急性肝损伤在事故发生后15天消退，但血清白蛋白和总蛋白仅在相当长的时间间隔（33至129天）后才恢复正常。此后没有残余肝损伤的迹象。急性肾损伤在事故发生后约一周达到高峰，肾脏重吸收钠和氯以及分泌钾和酸的功能在三周后几乎完全恢复。然而，肾脏重吸收水的能力，即产生浓缩尿液的能力，直到139天后才接近正常。根据肌酐和无机磷酸盐的清除值，在此时间间隔后未发现残余肾损伤。对结果的意义进行了讨论。
