克罗恩病中IgM的周转率
IgM turnover in Crohn's disease.
作者信息
Jensen K B, Goltermann N, Jarnum S, Weeke B, Westergaard H
出版信息
Gut. 1970 Mar;11(3):223-8. doi: 10.1136/gut.11.3.223.
Simultaneous turnover studies with radioiodine-labelled IgM and IgG were made in 12 patients with Crohn's disease. Intestinal protein loss was estimated by means of (59)Fe-labelled iron dextran. The serum levels of IgM, IgG, and IgA were normal in most cases. The catabolic rate of IgM was increased in all but one case. A positive correlation was present between the catabolic rate and serum concentration of IgM, an observation which, so far, has been made only in Crohn's disease. The synthetic rate of IgM was raised or high normal in four cases with an intraabdominal abscess. It was normal in the remaining cases. A strong positive correlation was found between the synthetic rates of IgM and IgG. The size of the protein loss was unrelated to the raised catabolic rates of IgM and IgG.Faecal radioiodine excretion from labelled IgM and IgG bore no relation to faecal (59)Fe excretion, nor did it indicate the site of the intestinal lesion. However, a close correlation was observed between faecal excretion of the labels from IgM and IgG.
对12例克罗恩病患者进行了放射性碘标记的IgM和IgG的同步周转率研究。通过（59）铁标记的右旋糖酐铁来估计肠道蛋白质丢失情况。大多数情况下，血清IgM、IgG和IgA水平正常。除1例患者外，其余患者的IgM分解代谢率均升高。IgM分解代谢率与血清IgM浓度呈正相关，迄今为止，这种现象仅在克罗恩病中观察到。4例伴有腹腔脓肿的患者，其IgM合成率升高或处于正常高值，其余患者的IgM合成率正常。发现IgM和IgG的合成率之间存在强正相关。蛋白质丢失的程度与IgM和IgG升高的分解代谢率无关。标记的IgM和IgG的粪便放射性碘排泄与粪便（59）铁排泄无关，也未表明肠道病变的部位。然而，观察到IgM和IgG的标记物粪便排泄之间存在密切相关性。
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