一种硝酸还原酶调控受损的粗糙脉孢菌突变体的生理学特性
Physiological characterization of a Neurospora crassa mutant with impaired regulation of nitrate reductase.
作者信息
Premakumar R, Sorger G J, Gooden D
出版信息
J Bacteriol. 1980 Nov;144(2):542-51. doi: 10.1128/jb.144.2.542-551.1980.
Abstract
This report describes the isolation and characterization of a Neurospora crassa mutant with an impaired regulation of nitrate reductase. Glutamine, which prevents the induction of nitrate reductase in N. crassa, did so relatively ineffectively in this mutant. The mutation did not affect the regulation of all enzymes regulated by "nitrogen metabolite regulation"; it did affect the regulation of nitrate reductase, nitrite reductase, histidase, and acetamidase, as well as that of thiourea sensitivity. The mutation was not allelic with nit-2, the gene controlling a general positive effector of nitrogen metabolite-regulated enzyme formation.
摘要
本报告描述了一种粗糙脉孢菌突变体的分离与鉴定，该突变体中硝酸还原酶的调控受损。谷氨酰胺可阻止粗糙脉孢菌中硝酸还原酶的诱导，但在该突变体中其作用相对较弱。该突变并不影响所有受“氮代谢物调控”的酶的调控；它确实影响了硝酸还原酶、亚硝酸还原酶、组氨酸酶和乙酰胺酶的调控，以及硫脲敏感性的调控。该突变与nit-2不等位，nit-2基因控制氮代谢物调控的酶形成的一般正效应物。
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本文引用的文献
1
Induction and repression of nitrate reductase in Neurospora crassa.粗糙脉孢菌中硝酸还原酶的诱导与抑制
J Bacteriol. 1961 Dec;82(6):898-904. doi: 10.1128/jb.82.6.898-904.1961.
2
SIMULTANEOUS INDUCTION AND REPRESSION OF NITRATE REDUCTASE AND TPNH CYTOCHROME REDUCTASE IN NEUROSPORA CRASSA.粗糙脉孢菌中硝酸还原酶和TPNH细胞色素还原酶的同时诱导与阻遏
Biochim Biophys Acta. 1965 May 18;99:234-45. doi: 10.1016/s0926-6593(65)80120-5.
3
Genetic control of nitrate reductase in Neurospora crassa.粗糙脉孢菌中硝酸还原酶的遗传控制
Genetics. 1965 Oct;52(4):777-88. doi: 10.1093/genetics/52.4.777.
4
Autoregulation of the synthesis of nitrate reductase in Aspergillus nidulans.构巢曲霉中硝酸还原酶合成的自动调节
J Bacteriol. 1969 Mar;97(3):1374-8. doi: 10.1128/jb.97.3.1374-1378.1969.
5
The regulation of nitrate reductase and catalase by amino acids in Neurospora crassa.粗糙脉孢菌中氨基酸对硝酸还原酶和过氧化氢酶的调控
Biochim Biophys Acta. 1968 Jan 8;151(1):20-32. doi: 10.1016/0005-2744(68)90157-5.
6
Induction and repression of amidase enzymes in Aspergillus nidulans.构巢曲霉中酰胺酶的诱导与抑制
J Bacteriol. 1970 Aug;103(2):482-7. doi: 10.1128/jb.103.2.482-487.1970.
7
Effects of ammonium, L-glutamate, and L-glutamine on nitrogen catabolism in Aspergillus nidulans.铵、L-谷氨酸和L-谷氨酰胺对构巢曲霉氮分解代谢的影响。
J Bacteriol. 1974 Dec;120(3):1116-23. doi: 10.1128/jb.120.3.1116-1123.1974.
8
Nitrogen metabolite repression in Aspergillus nidulans.构巢曲霉中的氮代谢物阻遏
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9
The role of molybdenum in the synthesis of Neurospora nitrate reductase.钼在粗糙脉孢菌硝酸还原酶合成中的作用。
Biochim Biophys Acta. 1972 Feb 28;256(2):533-43. doi: 10.1016/0005-2728(72)90081-3.
10
Allosteric interaction of D-glutamate with the glutamate dehydrogenases of Neurospora crassa.
Can J Microbiol. 1970 Dec;16(12):1341-9. doi: 10.1139/m70-221.
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