Kuckelt W, Dauberschmidt R, Meyer M
Acta Biol Med Ger. 1979;38(7):1007-12.
Acute respiratory insufficiency or adult respiratory distress syndrome is a common medical emergency in intensive medicine complicated by high mortality. To study the acute respiratory insufficiency under standardized conditions an animal model in Lewe-mini-pigs has been developed. This model is based on aspiration pneumonitis produced by intrabrochial atomisation of 0.2 N hydrochloric acid. General anesthesia was performed by neuroleptanalgesia. In all animals the profound changes in gas exchange, pulmonary mechanics and hemodynamics as well as quasi-static volume-pressure relationships after hydrochloric acid aspiration were described. The results suggest that this model is suitable to outline the profound changes in pulmonary function in this type of acute respiratory insufficiency.
急性呼吸功能不全或成人呼吸窘迫综合征是重症医学中常见的医疗急症，死亡率很高。为了在标准化条件下研究急性呼吸功能不全，已建立了一种Lewes小型猪的动物模型。该模型基于通过支气管内雾化0.2N盐酸产生的吸入性肺炎。采用神经安定镇痛进行全身麻醉。描述了所有动物在吸入盐酸后气体交换、肺力学和血流动力学的深刻变化以及准静态容积-压力关系。结果表明，该模型适用于概述此类急性呼吸功能不全中肺功能的深刻变化。
