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[通过动作电位的“相平面”轨迹研究电致乙酰胆碱对哺乳动物耳廓的作用]

[Electrotropic acetylcholine action on the mammalian auricle by means of the "phase plane" trajectories of the action potential].

作者信息

Nilius B, Boldt W

出版信息

Acta Biol Med Ger. 1979;38(7):987-98.

PMID:543376
Abstract

A single sucrose gap techniques has been used to study action potentials and phase plane trajectories of them in atrial trabeculae of the rabbit. Using polynomial representations of current-voltage relationships a model of membrane action potential of atrial myocardial fibres is described and allows an interpretation of recording data from the phase plane trajectories. Our findings show: 1. Increasing extracellular calcium concentration increases a potassium conductivity of the atrial membrane. 2. An anomalous rectification concerning repolarizing currents in atrial fibres decreases with increasing extracellular calcium. 3. Acetylcholine (3.10(-4) g.cm-3) abolishes the anomalous rectification. These results are discussed in relation to previous electrophysiological studies of negative electrotropic effects of acetylcholine in cardiac muscle.

摘要

一种单一蔗糖间隙技术已被用于研究家兔心房小梁的动作电位及其相平面轨迹。利用电流-电压关系的多项式表示法,描述了心房肌纤维膜动作电位的模型,并能对相平面轨迹的记录数据进行解释。我们的研究结果表明:1. 细胞外钙浓度的增加会增加心房膜的钾电导率。2. 心房纤维中与复极化电流有关的反常整流随着细胞外钙浓度的增加而减小。3. 乙酰胆碱(3.10(-4) g.cm-3)消除了反常整流。结合先前关于乙酰胆碱对心肌负性电变力作用的电生理研究对这些结果进行了讨论。

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