Böcker R, Estler C J
Arzneimittelforschung. 1979;29(11):1693-5.
By means of a newly developed high-pressure liquid chromatographic method the organ distribution of tetracycline (TC) and pyrrolidinomethyl-tetracycline (PMT) has been studied. When mice were treated with 50 mg/kg i.v. TC or PMT these antibiotics could be detected in all organs investigated (liver, kidney, heart, lung, muscle, spleen). Especially high concentrations were found in liver and kidneys, where TC and PMT could be detected up to 6 h. In animals treated with PMT part of the PMT applied decomposed slowly yielding TC, which was found together with PMT in blood and all organs.
通过一种新开发的高压液相色谱法，对四环素（TC）和吡咯烷甲基四环素（PMT）的器官分布进行了研究。当给小鼠静脉注射50mg/kg的TC或PMT时，在所有研究的器官（肝脏、肾脏、心脏、肺、肌肉、脾脏）中都能检测到这些抗生素。在肝脏和肾脏中发现了特别高的浓度，在那里TC和PMT在6小时内都能被检测到。在用PMT治疗的动物中，部分施用的PMT缓慢分解产生TC，在血液和所有器官中都发现了TC与PMT共存。
