Jull J W
Cancer Lett. 1979 Jan;6(1):21-5. doi: 10.1016/s0304-3835(79)80015-4.
Paraffin wax pellets were implanted surgically into the mouse bladder lumen and animals killed after 40-50, 70-80 and 100-110 weeks. The number and malignancy of bladder carcinomas increased considerably with the time after implantation. Pellets containing 1-phenylazo-2-naphthol significantly increased at each time the incidence of bladder carcinomas relative to that observed with paraffin wax. Pellets containing N-2-fluorenylacetamide or its metabolites gave very similar incidences or carcinomas whether or not they were carcinogenic by oral or parenteral administration.
将石蜡蜡丸通过手术植入小鼠膀胱腔内，分别在植入后40 - 50周、70 - 80周和100 - 110周处死动物。膀胱癌的数量和恶性程度随着植入后的时间显著增加。相对于石蜡蜡丸，含有1-苯基偶氮-2-萘酚的蜡丸在每个时间点都显著增加了膀胱癌的发生率。含有N-2-芴基乙酰胺或其代谢产物的蜡丸，无论经口服或非肠道给药是否具有致癌性，都产生了非常相似的癌发生率。
