Persson F
Acta Vet Scand. 1970;11(2):186-96. doi: 10.1186/BF03547979.
In order to investigate whether epidural analgesia in dogs employing mepivacaine chloride gives rise to complications, mainly changes in blood pressure, such analgesia was carried out in 35 dogs brought to the clinic for orthopedic, abdominal or perineal operations. Intra-arterial blood pressure measurements were made in 16 dogs. Three different solutions of mepivacaine chloride were used: 1 % solution with adrenaline 1:200,000; 2% solution with adrenaline 1:100,000 and 2% solution with adrenaline 1:200,000. The various solutions showed no significant difference in analgesic effect. Nor was any blood pressure change found during the epidural blockade. As a solution with a higher concentration causes a higher blood level of the analgesic and also greater toxic effects it is recommended that first preference be given to use of a 1 % solution with adrenaline 1:200,000; second choice is a 2 % solution with adrenaline 1:200,000 and third choice the 2 % solution with adrenaline 1:100,000.
为了研究在犬中使用盐酸甲哌卡因进行硬膜外镇痛是否会引发并发症，主要是血压变化，对35只送至诊所进行骨科、腹部或会阴手术的犬实施了此类镇痛。对其中16只犬进行了动脉内血压测量。使用了三种不同的盐酸甲哌卡因溶液：含1:200,000肾上腺素的1%溶液；含1:100,000肾上腺素的2%溶液和含1:200,000肾上腺素的2%溶液。各种溶液在镇痛效果上无显著差异。在硬膜外阻滞期间也未发现任何血压变化。由于较高浓度的溶液会导致镇痛剂在血液中的水平更高，且毒性作用也更大，因此建议首选含1:200,000肾上腺素的1%溶液；其次是含1:200,000肾上腺素的2%溶液，第三选择是含1:100,000肾上腺素的2%溶液。
