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二价阳离子对新城疫病毒(NDV)溶血的可逆抑制作用。

Reversible inhibition of Newcastle disease virus (NDV) haemolysis by bivalent cations.

作者信息

Apostolov K, Sawa M I

出版信息

Microbios. 1979;26(103):45-9.

PMID:545101
Abstract

The capacity of paramyxoviruses for haemolysis (hl) is enhanced after treatment with physical agents and complement (C'). Bivalent cations in the medium inhibit HL. The inhibition is proportional to the molar concentrations, and is graded Ba++ greater than Ca++ greater than Mg++. Substitution of the bivalent cations with K+ and re-incubation leads to reappearance of HL, but in reverse order. It is postulated that bivalent cations inhibit HL mainly by stabilising the virus membrane integrated into the erythrocyte membrane and slowing down the permeability rates. This inhibition is removed on substitution with monovalent cations. The bivalent cations also reversibly inhibit the permeability of the transferred C' lesion.

摘要

副粘病毒的溶血能力(hl)在用物理因子和补体(C')处理后会增强。培养基中的二价阳离子会抑制溶血。这种抑制作用与摩尔浓度成正比,且分级为Ba++>Ca++>Mg++。用K+取代二价阳离子并重新孵育会导致溶血现象再次出现,但顺序相反。据推测,二价阳离子主要通过稳定整合到红细胞膜中的病毒膜并减缓渗透率来抑制溶血。用单价阳离子取代后这种抑制作用就会消除。二价阳离子还会可逆地抑制转移的C'损伤的通透性。

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Microbios. 1979;26(103):45-9.
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