Apostolov K, Sawa M I
J Gen Virol. 1976 Dec;33(3):459-69. doi: 10.1099/0022-1317-33-3-459.
Pre-treatment of Newcastle disease virus (NDV) with fresh human plasma enhances its haemolytic (HL) capacity by several factors. The effect is due to complement activation by the heterophile anti-chick antibody present in human plasma. All the adult human plasmas tested were effective, also 91/100 human cord blood sera. The antibody was mainly of the IgM class. The enhanced HL was due to integration and transference of the complement 'holed' virus envelope membrane and subsequent leakage of haemoglobin. High concentration of activated complement destroys the integrity of the virus enevelope. Treatment of chick erythrocytes and fibroblasts with human plasma also produced lysis of the cells.
用新鲜人血浆对新城疫病毒（NDV）进行预处理可使其溶血（HL）能力提高数倍。这种效应是由于人血浆中存在的嗜异性抗鸡抗体激活补体所致。所有测试的成人血浆均有效，100份人脐带血血清中有91份也有效。该抗体主要为IgM类。溶血增强是由于补体“穿孔”病毒包膜膜的整合和转移以及随后血红蛋白的泄漏。高浓度的活化补体破坏了病毒包膜的完整性。用人血浆处理鸡红细胞和成纤维细胞也会导致细胞裂解。
