Toivanen P, Hirvonen T
Science. 1970 Oct 9;170(3954):187-8. doi: 10.1126/science.170.3954.187.
The ratio of males to females in 1061 babies born to mothers with toxemia of pregnancy is 1.24. The ratio increases as the severity of the disease increases, being 1.71 in cases in which the urinary output of protein is equal to or greater than 3 grams per 24 hours. Histoincompatibility of the fetus and mother, including incompatibility due to an antigen (or antigens) dependent on the Y chromosome, is suggested to function in the pathogenesis of pregnancy toxemia.
妊娠中毒症母亲所生的1061名婴儿中，男女比例为1.24。该比例随着疾病严重程度的增加而升高，在蛋白质尿量等于或大于每24小时3克的病例中为1.71。胎儿与母亲的组织不相容性，包括由于依赖Y染色体的一种或多种抗原导致的不相容性，被认为在妊娠中毒症的发病机制中起作用。
