Fakhri O
Br J Cancer. 1970 Jun;24(2):389-94. doi: 10.1038/bjc.1970.45.
The growth of ascitic mouse plasmacytoma 5563 has been monitored by (51)Cr-RBC dilutions within the peritoneal cavity together with differential cell counts and protein measurements.Following the intraperitoneal transplantation of one million tumour cells, there is a latency period of 4 days, possibly explained as only a 5% survival of the inoculum. This is followed by logarithmic growth from 4 to 8 days with a doubling time of 18 hours, always similar in different animals. Eventually after 8 days and after about 100 million cells an asymptote is reached which is due to a fistula-like communication between blood-stream and peritoneal cavity. This terminal phase (9-10 days) is rapidly followed by death of the mouse.Reliable tumour cell counts can only be achieved between 4 and 8 days.
通过腹腔内（51）铬 - 红细胞稀释法，结合细胞分类计数和蛋白质测量，对腹水型小鼠浆细胞瘤5563的生长情况进行了监测。在腹腔内移植100万个肿瘤细胞后，有4天的潜伏期，这可能是因为接种物仅有5%存活。随后在4至8天内呈对数生长，倍增时间为18小时，不同动物的情况总是相似。最终在8天后，当细胞数量达到约1亿个时，达到一个渐近线，这是由于血流与腹腔之间存在瘘管样连通。这个终末期（9 - 10天）之后小鼠很快死亡。只有在4至8天之间才能获得可靠的肿瘤细胞计数。
