对一个孤立的西印度群岛人群的研究：I. HLA基因型分析。

Studies on an isolated West Indies population: I. Analysis of HLA genotypes.

作者信息

Fumeron F, Feingold N, Bois E, Mayer F, Hors J

出版信息

Tissue Antigens. 1981 Mar;17(3):338-42. doi: 10.1111/j.1399-0039.1981.tb00709.x.

DOI:10.1111/j.1399-0039.1981.tb00709.x

Abstract

The transmission of HLA genes was studied in an isolated population of French origin on the lesser Antilles islands in the West Indies. The study of 74 unrelated individuals, 44 of whom were genotyped, was carried out for the alleles of HLA loci: A, B, C and Bf (proactivator factor of properdin). As a result of the founder effect and the inbreeding process, the HLA haplotypes were noted to be less polymorphic than in a French continental population. Two haplotypes: A2, Cw5, B12, BfS and A3, C-, B14, BfF represent 24% of the observed haplotypes, and only 2% of the reference haplotypes in France. No significant excess or deficit of homozygotes was observed at the A and B loci.

摘要

在西印度群岛小安的列斯群岛上一个起源于法国的孤立人群中研究了HLA基因的传递情况。对74名无关个体进行了研究，其中44人进行了基因分型，检测了HLA位点A、B、C和Bf（备解素前激活因子）的等位基因。由于奠基者效应和近亲繁殖过程，发现该人群的HLA单倍型多态性低于法国大陆人群。两种单倍型：A2、Cw5、B12、BfS和A3、C-、B14、BfF占观察到的单倍型的24%，而在法国参考单倍型中仅占2%。在A和B位点未观察到纯合子的显著过剩或不足。