[法国加泰罗尼亚地区人类白细胞抗原标记物的初步研究]

[Preliminary study of HLA markers in French Catalonia].

作者信息

Prévost P, Méneau P, Lefèvre-Witier P, Marcelli-Barge A, Poirier J C, Schmid M, Hors J

出版信息

Rev Fr Transfus Immunohematol. 1984 Apr;27(2):181-90. doi: 10.1016/s0338-4535(84)80036-7.

Abstract

Forty-two sets of parents and their two children, who had their origins for at least three generations in French Catalonia, were studied for HLA-A,B,C,DR and Bf alleles of the Properdine complement factors. Four haplotypes were observed to be in strong linkage disequilibrium (p less than 10(-3)): A1, Cw7, B8, DR3; Aw30 (Cw5), B18, BfF1, DR3; A1 (Cw6), B17; A29 or Aw23, Cw4, B12, BfF, DR7. The observed linkage disequilibria of these haplotypes in the French Catalonian population were compared with those already described among populations from the Basque country, the Toulouse area and Spanish Catalonia.

摘要

对42组父母及其两个孩子进行了研究，这些家庭在法国加泰罗尼亚至少已繁衍三代，研究内容为备解素补体因子的HLA - A、B、C、DR和Bf等位基因。观察到四种单倍型存在强连锁不平衡（p小于10⁻³）：A1、Cw7、B8、DR3；Aw30（Cw5）、B18、BfF1、DR3；A1（Cw6）、B17；A29或Aw23、Cw4、B12、BfF、DR7。将这些单倍型在法国加泰罗尼亚人群中观察到的连锁不平衡与已在巴斯克地区、图卢兹地区和西班牙加泰罗尼亚人群中描述的连锁不平衡进行了比较。