Tomlinson S, Hendy G N, O'Riordan J H
Lancet. 1976 Jan 10;1(7950):62-4. doi: 10.1016/s0140-6736(76)90152-5.
Hightly purified bovine parathyroid hormone (B.P.T.H) was given by injection and/or infusion to six normal volunteers and to patients with surgical hypoparathyroidism (five cases), idiopathic hyparathyroidism (five cases), or poeudo-hypoparathyroidism (six cases). Infusion and injection of B.P.T.H. produced very similar patterns of response in plasma adenosine 3' 5' cyclic monophosphate (cyclic A.M.P.) In all six normal volunteers and in the patients with surgical (five cases) or idiopathic (four cases) hypoparathyroidism who had injections of B.P.T.H., plasma-cA.M.P. had risen significantly within 5 min and the peak response was genereally observed 10 min after injection of hormone. In the five pseudohypoparathyroid patients who received injections of B.P.T.H., plasma-c?A.M.P. concentration increased only slightly or not at all after the hormone was administered. Unlike the traditional test for the investigation of hypocalcaemia, the test described here does not require collections of urine samples.
对6名正常志愿者以及患有手术性甲状旁腺功能减退症（5例）、特发性甲状旁腺功能减退症（5例）或假性甲状旁腺功能减退症（6例）的患者注射和/或输注高度纯化的牛甲状旁腺激素（B.P.T.H）。输注和注射B.P.T.H后，血浆3',5'-环磷酸腺苷（环磷酸腺苷）的反应模式非常相似。在所有6名正常志愿者以及接受B.P.T.H注射的手术性甲状旁腺功能减退症（5例）或特发性甲状旁腺功能减退症（4例）患者中，血浆环磷酸腺苷在5分钟内显著升高，并且通常在注射激素后10分钟观察到峰值反应。在接受B.P.T.H注射的5例假性甲状旁腺功能减退症患者中，给药后血浆环磷酸腺苷浓度仅略有增加或根本没有增加。与传统的低钙血症检查测试不同，此处描述的测试不需要收集尿液样本。
