MacDonald A S, Steele B J, Bottomley M G
Lancet. 1976 Jan 10;1(7950):68-70. doi: 10.1016/s0140-6736(76)90155-0.
The H-2-blocking antihistamine metiamide was used to treat 14 episodes of bleeding from the stomach or duodenum in eleven patients. In 11 instances bleeding was due to erosive gastritis or duodenitis and bleeding promptly ceased after one or two doses of 300 mg at 6 h intervals and did not recur as long as the drug was continued. In the 2 instances in which bleeding continued, chronic ulcers had eroded into major blood-vessels. There were no complications from the drug even in five patients with severe bone-marrow suppression after renal transplantation. Metiamide seems to be a safe and highly effective agent in the control of bleeding due to erosive gastritis.
H2 受体阻断型抗组胺药甲硫米特被用于治疗 11 例患者的 14 次胃或十二指肠出血。11 例出血是由糜烂性胃炎或十二指肠炎引起的，每隔 6 小时服用 300 毫克，服用一或两剂后出血迅速停止，只要继续用药就不会复发。在 2 例出血持续的病例中，慢性溃疡已侵蚀到大血管。即使在 5 例肾移植后有严重骨髓抑制的患者中，该药也没有引起并发症。甲硫米特在控制糜烂性胃炎引起的出血方面似乎是一种安全且高效的药物。
