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溃疡性结肠炎中的关节病、强直性脊柱炎和手指杵状指。

Arthropathy, ankylosing spondylitis, and clubbing of fingers in ulcerative colitis.

作者信息

Jalan K N, Prescott R J, Walker R J, Sircus W, McManus J P, Card W I

出版信息

Gut. 1970 Sep;11(9):748-54. doi: 10.1136/gut.11.9.748.

DOI:10.1136/gut.11.9.748
PMID:5473606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553102/
Abstract

In a retrospective study of 399 patients with ulcerative colitis, 27 patients had colitic arthritis, 17 had ankylosing spondylitis, and 20 had clubbing of the fingers. Colitic arthritis and ankylosing spondylitis were not related to severity, extent of involvement, or duration of colitis. A significant association between colitic arthropathy and other complications of ulcerative colitis, such as pseudopolyposis, perianal disease, eye lesions, skin eruptions, aphthous ulceration, and liver disease has been demonstrated. The outcome of the first referred attack of colitis in the presence of colitic arthritis and ankylosing spondylitis remained uninfluenced. Clubbing of fingers was related to severity, extent of involvement, and length of the history of colitis. A significant association between clubbing of the fingers and carcinoma of the colon, pseudopolyposis, toxic dilatation, and arthropathy has been shown. The frequency of surgical intervention in patients with clubbing was higher but the overall mortality was not significantly different from the patients without clubbing.

摘要

在一项对399例溃疡性结肠炎患者的回顾性研究中,27例患有结肠性关节炎,17例患有强直性脊柱炎,20例有手指杵状指。结肠性关节炎和强直性脊柱炎与病情严重程度、受累范围或结肠炎病程无关。结肠性关节病与溃疡性结肠炎的其他并发症,如假息肉病、肛周疾病、眼部病变、皮疹、阿弗他溃疡和肝脏疾病之间存在显著关联。在存在结肠性关节炎和强直性脊柱炎的情况下,首次发作的结肠炎的结局未受影响。手指杵状指与病情严重程度、受累范围和结肠炎病史长短有关。手指杵状指与结肠癌、假息肉病、中毒性扩张和关节病之间存在显著关联。有杵状指的患者手术干预的频率较高,但总体死亡率与无杵状指的患者无显著差异。

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本文引用的文献

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MEASUREMENTS OF BLOOD FLOW AND BLOOD PRESSURE IN CLUBBED FINGERS.杵状指的血流和血压测量
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THE ARTHRITIS OF ULCERATIVE COLITIS.溃疡性结肠炎相关性关节炎
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ANKYLOSING SPONDYLITIS AND CHRONIC INFLAMMATORY DISEASES OF THE INTESTINES.强直性脊柱炎与肠道慢性炎症性疾病
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Ann Rheum Dis. 1963 May;22(3):194-7. doi: 10.1136/ard.22.3.194.
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The arthritis of ulcerative colitis.溃疡性结肠炎相关性关节炎
Medicine (Baltimore). 1959 Sep;38:243-62. doi: 10.1097/00005792-195909000-00003.
6
The clinical course of arthritis associated with ulcerative colitis and regional ileitis.与溃疡性结肠炎和局限性回肠炎相关的关节炎的临床病程。
Arthritis Rheum. 1959 Dec;2:526-36. doi: 10.1002/1529-0131(195912)2:6<526::aid-art1780020607>3.0.co;2-x.
7
An association between ulcerative colitis, regional enteritis, and ankylosing spondylitis.溃疡性结肠炎、局限性肠炎与强直性脊柱炎之间的关联。
Q J Med. 1960 Oct;29:489-99.
8
The articular manifestations of chronic ulcerative colitis; an analysis of 555 cases.慢性溃疡性结肠炎的关节表现:555例分析
N Engl J Med. 1959 Aug 6;261(6):259-63. doi: 10.1056/NEJM195908062610601.
9
Arthritis associated with ulcerative colitis; a clinical and pathological study.与溃疡性结肠炎相关的关节炎;一项临床与病理学研究。
Ann Rheum Dis. 1958 Jun;17(2):169-83. doi: 10.1136/ard.17.2.169.
10
Hypertrophic osteoarthropathy and chronic ulcerative colitis.肥厚性骨关节病与慢性溃疡性结肠炎。
Gastroenterology. 1957 Sep;33(3):489-92.